1 . Changes in the structure and function of your brain from drug abuse make it impossible to safely stop using without professional intervention. If you are abusing any drug, whether prescription or illegal, your brain has adapted to its presence. Your body perceives a normal that is established by the dependence on the drug. Physical effects of drug addiction, as reported by the National Institute on Drug Abuse (NIDA) vary, depending on the drug, but can include heart rhythm irregularities and heart attacks; breathing difficulties and respiratory arrest; nausea, vomiting, and abdominal pain; poor musculoskeletal development, cramping and muscle weakness; kidney and liver damage; seizures and memory loss; and cancer.

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